1), was isolated from the liverwort Radula perrottetii Gottsche ex Steph in 1994 by Asakawa and co-workers and later from Radula marginata …
Certainly more preclinical studies of various models of chronic and inflammatory pain will be necessary to better understand its role in this setting.To obtain adequate amounts of PET from the liverwort plant, Gertsch collaborated with his colleague, Erick Carreira, whose team developed a new synthetic way to preserve the 3-D structure of the compound on a molecular level. A pea-sized chunk of R. marginata extract was collected, placed on foil and smoked. The THC scaffold was presumed unique to the Cannabis plant genus until the bibenzyl cis-THC, (−)-cis-perrottetinene (cis-PET) (Fig. I look forward to hearing how your further efforts go.So I'm confused. A recent study by a group of scientists in Bern, Switzerland examining a cannabinoid extracted from a rare moss-like plant--a member of the liverwort family--growing only in Japan, New Zealand, and Costa Rica has revealed potentially useful properties that may be valuable for people suffering with inflammation and chronic pain.Thus far, the researchers do not understand why this specific liverwort--which has a different way of living and reproducing compared with Cannabis—would harbor a compound so similar to tetrahydrocannabinol (THC), the psychoactive component found in marijuana. I know Radula Marginata … I really want to get every last bit of active material out, so I placed the jar in a water bath, ie, a pot with water boiling in it.
Why not just smoke the real stuff? Perottetinene is a natural cannabinoid produced in the genus Radula: Radula perrottetii; Radula marginata; Radula laxiramea; These grow in New Zealand, Costa Rica, and Japan. JavaScript is disabled. But THC is limited from a therapeutic standpoint due to a strong psychoactive effect at higher doses, other than being illegal at this time.As previously mentioned, in contrast to THC, PET inhibits the production of inflammatory prostaglandins in the brain.
Radula marginata is devoid of THC, but the …
This is similar to smoking mj?
Cannabis is no longer unique. Perhaps an experienced heroin smoker would be better at … Why go through all that trouble to have a similar high to mj when you are going to fail a test? Still do, but now have a little more encouragement that they are worth doing the work to answer them.Wow totally missed this one. "The present study is a prime example of how new synthetic concepts can make a contribution towards enriching our pharmacological knowledge of biologically-active natural substances", said Michael Schafroth, PhD, who studied and worked under the direction of Dr. Carreira, in a "Both solid fundamental research in the field of biochemical and pharmacological mechanisms as well as controlled clinical studies are required to carry out cannabinoid research", added Gertsch.With recent legalization of Cannabis in Canada helping to support ongoing support for research and patient interest in using combinations of CBD and THC to treat common conditions such as endometriosis, fibromyalgia and IBS, it’s becoming more apparent that the endocannabinoid system and its associated deficiencies may hold the key to relieving pain and alleviating bothersome symptoms that are difficult to treat.As clinicians seek less harmful modalities than opioids for treating chronic pain, PTSD, gastrointestinal, and autoimmune disorders, liverwort and its derivatives may hold promise as a safer therapy. I also serve as an adviser and editor to Medscape Emergency Medicine, an educational portal for physicians, and an affiliate of WebMD.
... of all the drug-stereotypes, its the diehard psychedelics-fans that tend to belittle other drug users, offer gibberish, cringey enlightenment, and go …
This was done to condense the acetone vapor back down to acetone so I wouldn't have to breath it in. This is what makes it more likely to contain cannabinoids. And it causes a + on a drug screen? This was extremely effective, there was virtually no hint of acetone in the air. As a result, PET likely has an effect on cannabinoid receptors which interact with our endogenous endocannabinoids. Interesting. "It's astonishing that only two species of plants, separated by 300 million years of evolution, produce psychoactive cannabinoids," said Gertsch in aAnd it turns out that the Maori people, indigenous to New Zealand, “The work of Jürg Gertsch and colleagues is a prominent advance in understanding the role of plants beyond cannabis on the endocannabinoid system,” said “Although this activity was proven via positive effects on the mouse tetrad of hypothermia (lowered temperature), catalepsy (frozen behavior), hypolocomotion (decreased movement) and analgesia (pain reduction), and was demonstrated to enter the brain, it is unlikely to become a major target of recreation users because of its relatively low potency and especially since liverworts are very slow growing and difficult to cultivate.” added Russo.Russo also explained that “perrottetinene differs from THC in a key way that makes it potentially useful medically, in that it reduces levels of prostaglandins D2 and E2 in the brain without producing COX inhibition, and thus may provide an effective anti-inflammatory and pain killer with a low risk of intoxication, formation of ulcers, or production of heart attacks or strokes.Russo explained that this finding should prompt additional biochemical prospecting in other liverwort species in this frequently overlooked group of “primitive” plants.“The stereochemistry of this compound suggests it may possess interesting clinical potential with minimized psychoactive side effect,” explained Raber. Long have had questions about this one.