However, Inaba spins his blade to the left to recreate one of Kenpachi's attacks, which injures Hitsugaya. Much of his upper body is then blasted away by Bazz-B's attack.

He has been noted to be one of the most common "fan favorite" characters from the series. He next appears in the Human World with several Shinigami and their respective Zanpakutō spirits, ready to help Ichigo fight Muramasa. Like Ichigo and Tatsuki, he also hates Orihime's weird food ideas and doesn't want anyone to eat her food.

Renji and Rukia then emerge and are overwhelmed by Gerard's new form, and Hitsugaya notes aloud that they are still alive. Hitsugaya then leaves to follow his own path with his grandmother's blessing. Cang begins to attack and points out that the Sternritter are taught to control the Bankai they have stolen. However, Hitsugaya notes that he summoned his bow a second too late as Gerard is frozen solid by Shikai Hyōketsu, which Hitsugaya explains is the result of his Bankai being able to freeze anything before it in four seconds. He is the most gifted prodigy the Soul Society has had since Gin Ichimaru, as shown from him entering the Shinigami Academy on his first try despite his young age, graduating from the academy in a single year with the highest written and performance scores in each of his classes, joining the Gotei 13 shortly afterwards, and then becoming the youngest Shinigami to ever reach the rank of a captain. During the fight, Hitsugaya attacked by enhanced Reigai-Byakuya Kuchiki.As Hitsugaya listens to Mayuri and Inaba's conversation, he witnesses Inaba attacking one of his Reigai allies. Eventually, he and Matsumoto are interrupted by a Hitsugaya returns back to the Central 46 Chambers in time to see Aizen alive and well. Mayuri requests that a detailed study be carried out and Hitsugaya is ordered to assist, along with Byakuya Kuchiki and Renji Abarai. Amagai takes out his Zanpakutō and attacks Hitsugaya, who blocks and asks him to pull back, but Amagai refuses. Hitsugaya attends a captain meeting where he is informed about Wandenreich's infiltration, and is ordered to prepare for war alongside other captains.

As Momo realizes the situation, she asks Hitsugaya if he is going to fight Captain Aizen. Mayuri may have decided to restore Hitsugaya's self-awareness after experimenting on him. He is easily annoyed by those who like to goof or like fooling around drawing unneeded attention to themselves, such as he was assigned to lead of few Soul Reapers as undercover high school students. Hitsugaya grows tired of waiting and states that he has never tried a particular ability in Bankai mode before, to which Harribel asks what he is talking about. !

However, Hyōrinmaru tells him not to push himself and to believe in the Shinigami. On the way, they encounter Captain Tetsuzaemon Iba who has just returned from training.

Hitsugaya and the other captains later gather outside Seireitei to witness the arrival of the Royal Guard. Further, the 13 seals of protection was still active and there was no signs of intrusion. Reprimanding Gerard for throwing around large objects that could fall on Seireitei like that, Hitsugaya cuts through the blade of Hoffnung before stating that its power has ceased to work because it is frozen, prompting Gerard to summon his Heilig Bogen.

He then reveals his never before seen power: Hyōten Hyakkasō. Mayuri then asks when he administered the medicine and swings his blade down on Hitsugaya, saying he should find out on his next trip back in time. Ever since he had been a captain, the only one he ever thought of as his subordinate was Gin. The two continue to battle to which Koga sustains many heavy injuries forcing him to absorb a large amount of spiritual particles to heal himself, but his body begins to reject the spirit particles.

He tells Aizen that he came to Karakura Town to kill him.Hitsugaya thinks he's managed to stab Aizen from behind...When Ichigo shouts at the Shinigami, questioning what they are doing, Tōshirō realizes that it was not Aizen that he has just stabbed. He is also a keen analyst, being able to deduce the basic mechanics behind an opponent's attacks, and quickly figuring out its strength and weakness to better counter it. Hitsugaya and Byakuya are then blown away by Kenpachi suddenly activating Bankai, transforming him into a red-skinned being. As Gerard overpowers Kenpachi, Hitsugaya and Byakuya begin their attack, but Gerard sees through their ploy and counters them. [84] Hitsugaya then confronts Hyōrinmaru, who appears to have lost his memory. He concludes it wouldn't be right to finish off a captain when he is weak and that to finish of Hitsugaya while he is in Bankai is far better.